Important Safety Information for Ozempic® (semaglutide) injection

What is Ozempic® Prescribed for?

Ozempic® (semaglutide) is a GLP-1 receptor agonist, a type of medication that helps regulate blood sugar, appetite, and digestion.

To support blood sugar control: Ozempic® is approved for use in adults with type 2 diabetes to help the body manage glucose levels when paired with balanced nutrition and regular physical activity. (FDA-approved)
Lower risk of cardiovascular events: For adults who have both type 2 diabetes and established heart disease, Ozempic® can help lower the risk of major cardiovascular events such as heart attack or stroke. (FDA-approved)
To help protect kidney health: For adults with type 2 diabetes and chronic kidney disease, Ozempic® has been shown to lower the risk of kidney function decline, kidney failure, and death related to cardiovascular disease. (FDA-approved)
To assist with chronic weight management: Some clinicians may prescribe Ozempic® to help with gradual, sustained weight reduction in adults who meet medical criteria for overweight or obesity. (Off-label)

Important considerations

Ozempic® is not for people with type 1 diabetes or those experiencing diabetic ketoacidosis.
It has not been evaluated in patients with a prior history of pancreatitis.
Dosing and treatment plans should always be personalized and monitored by your licensed healthcare provider.

Who should not use Ozempic®?

Do not use Ozempic® if you:

Have a personal or family history of medullary thyroid carcinoma (MTC).
Have a condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Have had a serious allergic reaction to semaglutide or any ingredient in Ozempic®.

How do I take Ozempic®?

Ozempic® is a once-weekly injection administered under the skin of your abdomen, thigh, or upper arm.

Use guidelines:

Take Ozempic® on the same day each week, with or without food.
Rotate injection sites weekly to avoid irritation.
Keep your medication refrigerated
Never share your injection pens or syringes.

Do not stop or adjust your dose without consulting your NavioMD clinician.

What should I tell my clinician before starting Ozempic®?

Before starting treatment, inform your healthcare provider if you:

Thyroid tumors or cancer
Type 1 diabetes (Ozempic® is not approved for this use)
Have or have ever had pancreatitis (inflammation of the pancreas).
Have kidney disease, liver disease, or gallbladder issues.
Have diabetic retinopathy (a type of eye disease).
Are pregnant, planning to become pregnant, or breastfeeding.
Depression, anxiety, or mood changes
Are currently taking insulin or other GLP-1 medications, which can increase the risk of low blood sugar.

Provide a complete list of all medications and supplements you take, including:

Prescription and over-the-counter drugs
Vitamins, minerals, or herbal products

Ozempic® slows stomach emptying, which may affect how your body absorbs oral medicines. Your clinician will help you determine how to space medications safely.

If pregnant or planning pregnancy:Ozempic® should not be used during pregnancy. If you are breastfeeding, discuss options with your provider, as it is unknown if Ozempic® passes into human milk.

Common side effects

The most common side effects of Ozempic® tend to occur early in treatment or when dose adjustments occur. Side effects may include:

Nausea
Vomiting
Diarrhea
Constipation
Abdominal discomfort
Fatigue

If you continue to experience side effects, please contact your NavioMD provider by starting an Urgent Care Visit through your patient portal.

Serious side effects and warnings

Ozempic® can cause serious side effects. If you experience any of the following, seek immediate medical care right away:

Possible thyroid tumor: It is not known whether Ozempic® causes thyroid tumors in humans; however, there have been rare reports of MTC in patients taking similar medications after approval. In animal studies, an increase in thyroid tumors, including medullary thyroid carcinoma (MTC).
- Ozempic® should not be used if you or a family member have ever had MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
- Tell your provider right away if you notice a lump or swelling in your neck, hoarseness, difficulty swallowing, or shortness of breath.
Pancreatitis: Ozempic® may cause inflammation of the pancreas, which can become a serious medical condition.
- Seek medical attention if you develop severe, persistent stomach pain (with or without vomiting) that may radiate to your back.
Vision changes: Blurred or sudden changes in eyesight.
Low blood sugar (hypoglycemia): Shaking, sweating, dizziness, confusion, or rapid heartbeat.
Kidney problems: Fatigue, swelling in legs or ankles, or reduced urination — especially if dehydrated.
Gallbladder issues: Upper abdominal pain, fever, yellowing of the skin or eyes, or pale stools.
Severe allergic reaction: Rash, swelling of the face or throat, or trouble breathing.
Increased heart rate: Rapid heartbeat while at rest.
Mood changes or suicidal thoughts: Contact your provider if you notice new or worsening depression or anxiety.

If you are experiencing a medical emergency, call 911 or seek immediate medical attention.

Reporting side effects

If you experience mild side effects, contact your NavioMD clinician through the patient portal for personalized guidance.If you are having a medical emergency, call 911 or go to the nearest emergency department immediately.

For product-related questions or to report side effects, you can contact Novo Nordisk www.novonordisk-us.com/contact-us.html

If you experience negative side effects, you can report them to:

FDA MedWatch: www.fda.gov/medwatch or call 1-800-FDA-1088

Disclaimer

This information is provided for educational purposes and does not replace professional medical advice. Always consult your licensed healthcare provider for diagnosis, treatment, and personalized recommendations. For full details, please review Ozempic® Prescribing Information.

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